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However, there is evidence from TbNMT inhibitors that a substantial window of selectivity can be derived between HsNMT1 and TbNMT despite highly similar active site structures.
A substantial window of opportunity for improvements in functional outcome by G-CSF treatment is also suggested by Lees et al. [ 8], who report effects in rotarod measurements particularly when treatment was delayed to 1 day and longer after MCAO.
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Still, there are substantial windows of opportunity for action towards evidence-informed policymaking through the development of new health system strategic plans, and reform initiatives in the region.
The network showed no substantial window size dependency on the quality of predictions, regardless of the number of hidden units, or scoring (Supplementary Fig. S2).
In fact, zVAD-FMK gave an IC50 value of 230 nM in our Fas-assay (data not shown), indicating that there is a substantial window between the anti-apoptotic and T-cell-suppressive activity of caspase inhibitors in general.
No substantial window narrowing was observed.
At its earning call last month, Nokia — the only substantial Windows Phone OEM (controlling 90% of the market according to AdDuplex) — revealed it sold a total of just 30 million Lumia devices during in the whole of 2013.
There is substantial evidence that genetics, obesity, and the window of exposure (fetus, infant, elderly) are major susceptibility factors in the pathogenesis of asthmatic disease.
In particular, we argue that adolescence represents an additional window of opportunity during which substantial life cycle and intergenerational effects can be accrued.
Moreover, simply processing the tweets over a relatively small window of time (e.g., weeks) requires substantial computational power.
As UK shale gas is not expected to be produced in substantial quantities until the 2020s, that leaves a small window of opportunity for investors in the industry.
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