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No substantial window narrowing was observed.
However, there is evidence from TbNMT inhibitors that a substantial window of selectivity can be derived between HsNMT1 and TbNMT despite highly similar active site structures.
A substantial window of opportunity for improvements in functional outcome by G-CSF treatment is also suggested by Lees et al. [ 8], who report effects in rotarod measurements particularly when treatment was delayed to 1 day and longer after MCAO.
In fact, zVAD-FMK gave an IC50 value of 230 nM in our Fas-assay (data not shown), indicating that there is a substantial window between the anti-apoptotic and T-cell-suppressive activity of caspase inhibitors in general.
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The other twist here: no new Lumia smartphones being unboxed by Nokia, the only substantial Windows Phone OEM, at the world's largest mobile devices conference.
At its earning call last month, Nokia — the only substantial Windows Phone OEM (controlling 90% of the market according to AdDuplex) — revealed it sold a total of just 30 million Lumia devices during in the whole of 2013.
Still, there are substantial windows of opportunity for action towards evidence-informed policymaking through the development of new health system strategic plans, and reform initiatives in the region.
Those now proved no more substantial than window shades, and yet, for three good years, they'd got to feeling pretty monumental.
Both PS/PPO and PPO/p oClS pClS) binary blends exhibit single glass transition temperatures over the full composition range whereas the PS/p oClS pClS) system displays a substantial immiscibilty window which extends into the ternary phase diagram.
This represents a substantial time window during which sepsis could potentially be diagnosed and treated earlier.
Given the promising initial in vitro culture studies of the proteasome inhibitors that revealed a substantial therapeutic window (Table 1), we wanted to assess the effects of these compounds on parasite growth in vivo.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com