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The phrase "substantial weakness is" is correct and usable in written English.
It can be used when discussing a significant flaw or deficiency in a particular context, such as in a report or analysis. Example: "The substantial weakness is evident in the lack of proper funding for the project, which has hindered its progress."
Exact(2)
Perhaps the most substantial weakness is the lack of a clear demonstration of the use of synonymous rates of evolution.
The result is that I am totally convinced that the authors are correct in their conclusions and the only substantial weakness is that they don't go a little farther in the interrogation of the MICOS complex or the QIL1 protein.
Similar(58)
Deutsche Bank failed the test in 2015, and failed again this June, when "broad and substantial weaknesses" were uncovered.
Despite the fact that the district members attending this planning session were educated at the diploma level and above, substantial weaknesses were revealed in terms of a lack of knowledge on how to properly plan employing the allocated ceilings.
Her weakness is shoes.
Weakness is her forte.
The weakness is pervasive.
Weakness is bad.
Nevertheless, the inability to test hypotheses about location and causality in later interviews represents a substantial weakness and should be tested in further studies.
While few countries do as much as the UK to assist homeless people, there is still a substantial weakness in our system, which is the approach taken by the judiciary in England and Wales.
My weakness was jewelry".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com