However, substantial variation has been reported among pluripotent cell lines, which could affect their utility and clinical safety.
Therefore it is not surprising that substantial variation has been found among experiments.
Moreover, allele frequencies for both genes are known to not only differ among major ethnic categories such as European, Asian, and African American, but substantial variation has also been demonstrated in subpopulations of each[44], [62] [67].
While little variation is seen within different laboratories, substantial variation has been documented between different laboratories in general and between different ELISAs in particular [ 42].
Substantial ethnic variations have been found in incidence, pathways to care and outcomes in psychosis.
Concentrations of greenhouse gases have varied substantially during Earth's history, and these variations have driven substantial climate changes at a wide range of timescales.
However, the ability of HIV-1 to evade host immune defenses, along with substantial genetic variation, has posed major stumbling blocks to thwart this effort [2].
Substantial natural variation has been detected in clock-affecting genes, based upon assays of rhythmic leaf movement under constant light [ 9- 11].
With regard to ethnical differences, substantial racial variation has been observed in the incidence of ovarian cancer, with highest rates in Caucasian women and lowest rates among Asian women [ 138].
Susceptibility of P. falciparum parasite lines can be tested in vitro, and substantial genetic variation has been shown in this context (Beez et al. 2011), but it remains unclear how this relates to susceptibility and infection dynamics in the host.
