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It is important to note that a missing correlation between the disconjugacy of their saccades and the disconjugate drift during fixations reflects that the vergence adjustments did not work in a systematic manner, thus, causing a substantial variability of the vergence angle during reading fixations.
Besides the small number of patients included, a major limitation of this study is the substantial variability of the measurements of substrate metabolism themselves.
This lack of phylogenetic coherence could be due to the imperfect detection of phagosomal proteins with the applied proteomics methods, the substantial variability of the phagocytosis machinery or, most likely, by a combination of both these factors.
Substantial variability of the data may be due to small numbers of samples analyzed (in some of the studies), to utilization of different types of monoclonal antibodies, to different criteria used by different research groups for the results interpretation, etc.
Even though the manifestation of the basic defect at the cellular and epithelial levels is less vulnerable to environmental influences than any clinical outcome parameter such as lung function, growth and stature, substantial variability of the basic defect phenotype among sib pairs with shared CFTR mutation genotype is observed.
These observations together with a substantial variability of the onset kinetics in RT neurons (for non-saturating [GABA]) suggest that although α3-subunit-containing receptors play a major role in determining the kinetic behavior of GABAergic currents in patches from RT neurons, probably also other receptors could be involved.
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Although the custom array card included internal controls (U6 and RNU66 for mature miRNAs; beta-actin and GAPDH for the precursors) in the panel, we could not rely on these controls to normalize the data because of the substantial variability of these genes expressed in tissues and cells (Tables S3, S4 and S5).
2) In Figure 2, I am surprised by the substantial variability of background uptake in the absence of the protein.
Given the substantial variability of interventions in cardiac rehabilitation trials, it is pertinent to explore whether the differences in exercise interventions are contributing to the differences in observed effectiveness.
This finding is consistent with the substantial variability of symptoms in this region, in which both neurotoxic and classical envenomations are reported (Figure 14).
Estrogens and other hormones with growth enhancing properties are abundant during pregnancy, and adult life exposures do not fully explain the substantial variability of breast cancer occurrence between and within populations.
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Justyna Jupowicz-Kozak
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