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PCP hydroxylase (PcpB) has a very low kcat of 0.02 s−1 and shows substantial uncoupling; the enzyme frequently fails to hydroxylate the substrate and instead releases H2O2 as the C4a-hydroperoxyflavin intermediate decomposes (Hlouchova K, Rudolph J, Pietari JMH, Behlen LS, Copley SD, unpublished data).
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Indeed, there's a strong argument for uncoupling the music from the apps entirely.
Uncoupling the peripheral clock from the central clock by RF leads to a substantial, but transient intrahepatic accumulation of bile acids that induces liver stress response and injury, while genetic ablation of both Per1 and Per2 results in markedly high serum bile acid levels with moderately elevated hepatic levels.
It would require substantial additional work to define the precise molecular mechanisms responsible for the interesting observation of Per1 mRNA-protein uncoupling.
Name: Conscious uncoupling.
"Feel it," she urged, uncoupling the magnet.
"After a period of denial, we've chosen conscious uncoupling.
That's what Harari means by the "uncoupling" of intelligence and consciousness.
The Ripley Guide, uncoupling the species from S. leucopsis.
Gwyneth Paltrow, Chris Martin split, call it 'conscious uncoupling'.
Furthermore, uncoupling can prevent ROS formation in mitochondria [ 27].
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