Sentence examples for substantial uncertainty around from inspiring English sources

Although the studies suggest that the introduction of an HPV vaccine could be cost effective compared with current practice in the USA, there is still substantial uncertainty around key variables, and model validation seems insufficient.

The worksite health promotion intervention from the Netherlands [36] also has a median cost-effectiveness ratio under $50,000 per DALY, but there is substantial uncertainty around intervention effectiveness, leading to only a 50% probability that this intervention will be cost-effective if rolled out in Australia.

Probabilistic sensitivity analysis revealed substantial uncertainty around these point estimates.

However, there remains substantial uncertainty around incremental QALY gains.

Second, there is substantial uncertainty around future events.

32 However, the imprecision around QALY differences means that there is substantial uncertainty around this ICER.

Although the EVI analyses suggested substantial potential value from a large, multicentre RCT evaluating the clinical effectiveness of IVIG in this population, there remain significant uncertainties around the design of a study (with respect to, for example, the dose or duration of therapy with IVIG).

Is this situation creating substantial uncertainty and hurting the economy?

But they also both involve substantial uncertainty related to timing and severity.

Of course, CBO Director Douglas Elmendorf notes that these preliminary estimates are subject to "substantial uncertainty".

There is substantial uncertainty regarding the efficacy of antidepressants in the treatment of bipolar disorders.