Conversely, it is unlikely that we missed substantial randomised trial data on exercise, thus the relative dearth of evidence on exercise versus evidence on drugs may be even more prominent.
In this fashion, the ACCE Method may prove useful for estimating at least the likely general size and direction of residual confounding in the many circumstances where substantial randomized trial data is not available to guide one's interpretation.
On the other hand there is vast experience with and substantial clinical trial data for so-called selective digestive tract decolonization (SDD) regimens in intensive care patients and in neutropenic cancer patients in whom preventive treatment with nonabsorbable drugs like colistin plus tobramycin can decrease the risk of infection due to gram-negative enteric bacteria [ 6].
Substantial epidemiological evidence and significant clinical trial data suggest that vitamin D intake can have important effects on the risk of falls, cancer, cardiovascular disease and other health effects.
Substantial randomized controlled trial data from the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications exists to support postponement, but not outright prevention, of GFR loss in normoalbuminuric patients.
In Japan, substantial domestic clinical trial data are included in a new medicine application data package.
20 The inclusion of data from the shorter studies (2 weeks and 6 weeks) comparing aclidinium and tiotropium would require substantial extrapolation of the trial data, which would increase uncertainty in the outcomes of the analysis.
Clinical trial data demonstrate substantial reductions in CHD events with lipid-lowering therapy among women [47].
Different modelling assumptions and extrapolation of trial data can generate a substantial variability in outcomes, highlighting the importance of validating findings with follow-up comparative effectiveness research such as this study.
Herd protection has been inferred for Dukoral according to a reanalysis of the Bangladesh original clinical trial data and has been suggested to be substantial in cholera-endemic areas.
