Sentence examples for substantial trail from inspiring English sources

She has no steady source of income and has a substantial trail of unpaid bills, battles with the Internal Revenue Service and questionable use of campaign donations for personal expenses.

The letters and other documents leave what Mr. Forcellino says is a substantial trail for the painting from Colonna to an English cardinal, Reginald Pole, a cousin of Henry VIII and another member of the spirituali, who appears to have taken it with him as a devotional object when he attended the Council of Trent, the 16th-century Catholic ecumenical conclave that began the Counter-Reformation.

The half‐peak widths for all gene features were ~2 kb, but in each case there were substantial trailing edges extending beyond 10 kb of the feature reflecting contributions from regional modifications.

She has a powerful and varied résumé and has produced a substantial paper trail.

The modestly proportioned 28km-long, 19km-wide-island offers copious rewarding trekking, cycling and camping opportunities in addition to abundant beaches and a substantial drool trail leading from one Slow Food-endorsed dinning establishment to another.

One of these is hiking and a substantial investment in trail development by the Chinese State commenced in 2014.

Histological analysis showed a substantial number of TRAIL positive cells in the tumor tissue infected with AAV/TRAIL alone and combination of AAV/TRAIL plus cisplatin, but few in the tumor tissue infected with AAV/null.

There was no difference in Bcl-2 expression; however, there was a substantial decrease in TRAIL expression when mice were treated with both pmel and TRP-1 T cells (Fig 5B), implying the addition of tumor-specific CD4+ T cells increases CD8+ T-cell persistence by reducing exhaustion by the PD-1 pathway and decreasing TRAIL-induced apoptosis.

Following 5-FU treatment, we detected a substantial rise in TRAIL-R2 expression but almost no effect on the TRAIL-R1 levels.

In summary, TRAIL-R-specific variants offer a substantial improvement over normal TRAIL as they can better target TRAIL-resistant cellsr cells and act more specifically and effectively in combined treatment approaches.

These results demonstrate that, while TRAIL-receptor specific variants constitute a potentially substantial improvement to conventional TRAIL therapies, generalised predictions according to cancer type are difficult.