Sentence examples for substantial toxicity from inspiring English sources

"There is risk of substantial toxicity, and it doesn't work on everybody.

However, these doses are associated with substantial toxicity and are poorly tolerated10,11.

Whereas radiation has been associated with a decreased rate of locoregional failure, the treatment is also associated with substantial toxicity.

Given the substantial toxicity of PORT we assessed lymph node ratio (LNR) as a predictor of PORT benefit.

Naturally derived antioxidants could play significant roles in cancer therapy due to their multi-targeted actions and lack of substantial toxicity.

While these vectors have proven to be quite efficient, they are associated with substantial toxicity due in part to capsid mediated activation of innate immunity and local and systemic inflammation [15], [16].

Lipopeptides, such as polymyxin B and colistin, are potent against particularly Gram-negative bacteria, but also display substantial toxicity [22], the latter possibly related to membrane composition-independent incorporation of acyl groups in a way comparable to that of peptides of high hydrophobicity [21].

Both are associated with substantial toxicity [ 12].

Moreover, conventional combination chemotherapy may be associated with substantial toxicity.

Unfortunately, amphotericin B has been associated with substantial toxicity.

These combination treatments are associated with substantial toxicities and a median duration of responses in the order of months.