Sentence examples for substantial toxic effects from inspiring English sources

People with drug-resistant disease must endure two years or more of grueling treatment, often with drugs that must be injected and have substantial toxic effects.

Importantly, the mean weight of animals treated with L.s.-P or its fractions did not differ from that of control animals, and no significant histopathologic changes were observed in sections of liver, spleen and lung of treated versus untreated mice (data not shown), suggesting that fucoidans or their purified fractions have no substantial toxic effects at least at the concentrations tested.

Indeed, adjuvant polychemotherapy has substantial toxic effects (around 60%70%% grade 3 or 4 adverse events), 124 more grade 4 hematologic toxicity, more treatment discontinuation for toxicity, and more acute myeloid leukemia/myelodysplastic syndrome (1.8%).

For example, it was found that when cipA*, discussed in detail below, was placed downstream of the native T. saccharolyticum pta/ ack promoter, this resulted in substantial toxic effects to E. coli.

Therefore, a substantial toxic effect on human health can be expected.

No significant toxic effect is imposed on the cells.

There was a statistically significant toxic effect (Fig. 5).

Additionally, it produces substantial mucocutaneous toxic effects and, similarly to methotrexate, is teratogenic.

Among the animal feeding studies and reviews of such studies in the list, a substantial number found toxic effects and signs of toxicity in GM-fed animals compared with controls [29-34] [29-34]

This search could not only lead to an oncological approach of unlimited addition that we will not be able to afford, but would also end inevitably in indeterminate overtreatment with substantial risks of unexpected toxic effects eating away whatever progress we might make.

Although these patterns of drug administration, which we recently entitled METH preconditioning [18], provide substantial attenuation of the toxic effects on monoaminergic systems, the involved neuroprotective mechanisms have remained mysterious.