"substantial time constraints" is a correct and usable phrase in written English.
It refers to a significant limitation or restriction on the amount of time available to complete a task or activity. Example: Due to the substantial time constraints of the project, we were unable to incorporate all of the proposed ideas into our final presentation.
GPs already work within significant time constraints.
For example, one prior feasibility study examining the use of an HRQL-HIT application in 14 German general practices found substantial variation between practice sites and identified time constraints as a substantial barrier to both collecting and effectively using the HRQL information [ 10].
Ideally, the diagnostic process is studied prospectively in a real clinical setting, but this poses substantial practical difficulties (eg, ethical issues, time constraints, measuring clinician thought processes unobtrusively, observer bias).
However, there is no direct evidence that time constraints on genome replication are substantial enough to influence the mutation rate, except perhaps in viruses (Furió et al. 2005, 2007).
Crisis situations increase the chance of overlooking essential steps in outbreak management because of time constraints, uncertainty, and the lack of substantial evidence in effective approaches to controlling new diseases.
Time constraints and limited interest in the study were substantial.
4 17 Although effective, the cost and time constraints of this data collection method can be substantial, particularly in large studies where subjects are geographically dispersed.
With substantial technician coaching, the problem can usually be resolved; however, due to time constraints this may not always be possible.
This can be readily explained if the loss of constraint and the subsequent ORF disruption occurred a substantial time after the divergence of the lineage, since in this case ω calculated for the lineage is a mixture of earlier evolution under constraint and later neutral evolution.
Advantages include the absence of time constraints or supervising faculty, uniform training scenarios of adjustable complexity and pathology as well as substantial saving from costly disposable equipment and training time within the operating room [ 15, 23].
