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If "The Witches of Eastwick," which has few substantial thoughts in its head, has a moral, it is that you should never underestimate the power of being female, 40-ish and sexually ripe.
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Thus, Malebranche's skid to Spinozism is greased even when he talks about mind, the essence of which is thought not this or that thought, "but substantial thought, thought capable of all sorts of modifications or thoughts".
But to keep the gala crowd on opening night from having to bother its pretty, reveling heads with any substantial thought, Mr. Adams's work will be replaced that once by Beethoven's "Leonore" Overture No. 3. (Well, you know, there's still the theme of liberty and all that).
Substantial thought and angst has been expended over the fact that artificial intelligence (AI) is coming to your workplace to take over blue- and white-collar jobs, alike.
Since the same substantial thought is had by all possessed of a mind, Malebranche's view smacks even of the single intellectual soul for all men of the Latin Averroists.
The point of Leibniz's analogy between substantial thought or perception and God's conservation is to reveal two important aspects of emanation: (1) that God's causal influence on us in continual (just as substances always perceive); and (2) that this influence doesn't diminish God's causal power (just as thinking doesn't seem to diminish our ability to think) (Mercer, 189).
After substantial thought, Owen reluctantly decides to join Cristina at her abortion, uniting the two.
As the BPC (2009) noted, substantial thought should be devoted to determining what constitutes a conflicting or competing interest and to balancing the goal of promoting disclosure against investigators' legitimate interests in privacy and minimizing burdens.
The recruitment of sufficient numbers of patients to achieve statistical power, the development of reliable methods to measure the bone repair endpoint, and the randomization of patients to treatment groups in an ethical experimental design require substantial thought and planning.
While the $1,000 genome is probably only a few years away, and this would make sequencing of DNA across tumours affordable, to create enormous catalogues of genomic information without giving substantial thought to study design is likely to be frustrating and of limited value.
Evaluation of the requirements of non-medical prescribing courses is underway, but substantial further thought needs to be applied to ensure reproducibility of these results in a larger sample and consistent production of safe and effective prescribers.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com