Recent reference data from the QUASAR2-trial [ 17] proved that up to 30%% of patients suffer from substantial therapy-induced symptoms during active therapy.
In order to accelerate the development of aFRLM into a substantial clinical therapy, further studies are required, including investigations of the pharmacodynamic and pharmacokinetic properties and the metabolism of aFRLM in vivo.
Therefore, we are unable to conclude from our review whether or not the MOS-HIV is sensitive to more substantial ARV therapy modifications in treatment-experienced patients, such as switching from an NNRTI-based regimen to a PI-based regimen.
Improvements in lung function (ie, mean placebo-adjusted increase in trough FEV1 of 51 mL) were consistent with those observed with other approved bronchodilators in a population with mostly severe airflow limitation who were receiving substantial background therapy.
The personal and financial costs of IPF are substantial, and therapies to reduce the burden of illness from IPF are sorely needed.
Low patient adherence is a substantial problem in therapy.
Using cognitive behavioral therapy, substantial improvements for anxious chronic pain patients can be envisaged through exposure designed in view of extinction (by learning) of inhibition.
While durable complete remission remains an elusive goal in the treatment of AIPC, substantial responses to therapy are frequently reported.
Although TRAIL is a potent apoptotic trigger in many cancer cells, resistance to TRAIL, either intrinsic or acquired, currently represents a substantial limitation to therapy [ 33].
This is mainly based on the potentially reversible character of these diseases and the substantial progress in therapy within the last decades [ 27, 28].
