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However, such TEHV are associated with substantial technological and logistical complexity and have not yet entered clinical use.
Those who favor military action are again making the threat appear closer than it is by minimizing the substantial technological and engineering obstacles that Iran must overcome to be able to enrich uranium and manufacture a weapon.
This will require the adaptation of the existing equipment, raising substantial technological and image analysis challenges.
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In a statement this month Fannie Mae said that it had conducted small-scale pilot programs and determined that principal reduction poses a number of challenges, "including significant technological and systems complexity and substantial cost without proven effectiveness".
Finally, given that antibiotic resistance is now a major public health challenge, and that we might be entering a 'post-antibiotic era' (Woolhouse and Farrar, 2014), these findings could represent a substantial technological advance and an important first step to addressing the problem of diagnosing and properly treating enteric fever and other blood-borne infections.
Bitcoins can currently only be bought and sold on informal computer networks and on online marketplaces that require substantial technological savvy and are far more complicated than traditional exchanges.
According to the strategy paper that was leaked by the Russian Foreign Ministry, Russia will need at least €1 billion until 2013 to upgrade its infrastructure as part of its modernization program, but also substantial technological assistance and investments from abroad.
"The real price of cosmetic surgery has declined over the past 15 years, despite substantial technological progress and a sixfold increase in demand".
Augmentation of IceCube with large-scale (1000km3sr) radio and acoustic arrays would extend the physics reach of IceCube into the EeV ZeV regime and offer substantial technological redundancy.
Lipopolysaccharide (LPS) has been proved to circulate after cardiac surgery with CPB [ 2] and, despite substantial technological improvements in past decades, an acute transcriptional response of genes involved in the innate immune response occurs, which can lead to systemic inflammation and postoperative organ dysfunction [ 3].
The development of multislice technology represents a substantial technological advance in CT.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com