Sentence examples for substantial systemic from inspiring English sources

Current anti-rejection medications, such as antibodies and small molecule drugs, target the immune systems of the organ recipient, which can cause substantial systemic effects.

This will have very substantial systemic benefits for the derivatives market and for the banking system as well.

Exposure to certain chemicals carries the risk of substantial systemic toxicity and even mortality.

These data, along with the determined changes suggest that TCA produce substantial systemic organ toxicity in rats during the period of a 52-day subchronic exposure.

A logical aim for initial siRNA translation is local therapies, as delivering siRNA directly to its site of action helps to ensure that a sufficient dose reaches the target tissue, lessens the potential for off-target side effects, and circumvents the substantial systemic delivery barriers.

Suffering from any substantial systemic, neurological or psychiatric disease.

When law-abiding behavior was absent and a breach of legal standards was substantial, recurrent, or systemic, then financial penalties were imposed.

We show that by using biocompatible excipients already approved for human use, one could engineer microparticles that induce substantial local and systemic immunity subsequent to pulmonary administration.

Advances in our understanding of immune checkpoints and the mitogen-activated protein kinase pathway (MAPK) have driven substantial improvements in systemic treatments for melanoma.

On this basis, cytokine gene-transduced tumor cells have widely been used as vaccines in clinical trials, which have shown good safety profiles and some local responses but substantial lack of systemic efficacy.

In stark contrast to the public yet artificial perfection of Beijing's Olympics stand the substantial civic and systemic challenges of past events in Atlanta and Athens.