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To date the only treatment leading to substantial, sustained body weight loss is bariatric surgery.
Mn2+ quenching of the Ca2+ indicator dye revealed substantial sustained divalent cation influx into the hyperpolarized cone IS.
Our findings suggest that ivacaftor treatment led to significant improvements that were substantial, sustained over 48 weeks, and spanned a wide range of symptoms, functioning, and well-being in patients with the G551D-CFTR mutation in the STRIVE study.
Plasmalemmal EYFP fluorescence formation was observed even though full-length STIM1 EYFP did not reveal substantial sustained puncta formation under these conditions (results not shown) suggesting that an increase in cytosolic Ca2+ from intracellular stores modulates the interaction between STIM1-CT and Golli-BG21.
Only in the late nineteen-nineties, after Sellars published his influential and critical book, did the agency dedicate substantial, sustained funding to the inventory and monitoring of its natural resources.
Tim Geithner: The most important thing is you see unemployment coming down definitively; very substantial sustained reductions in unemployment.
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"Making a real difference for internally displaced people will require a very substantial and sustained commitment of resources".
That defense was substantial and sustained.
"What the record demonstrates is a substantial and sustained commitment to combatting terrorism," said Joel Kaplan, deputy director of the Office of Management and Budget.
But his role in the case had been so substantial and sustained, the presiding judge felt compelled to address the parents' concerns.
Its authors said that, without "substantial and sustained" emissions reductions, the 2C limit set by the world's governments would be breached, resulting in heatwaves, droughts and more extreme weather.
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