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While positions 189 192 formed an exposed loop in HSPA1A, the longer peptide of 25 aa involved more substantial structural elements, including an extended loop followed by a mostly-buried alpha-helix.
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Some introns contain various regulatory elements as well as sequences involved in chromatin structure formation such as scaffold-matrix attachment regions, although it remains uncertain whether intron sequences show any substantial enrichment for regulatory and structural elements compared to other non-coding DNA [ 214, 246].
This data set is attractive because the target has been a major focus of research on anti-inflammatory drugs and because it combines substantial structural variation with a few key shared elements such as the distal sulfonyl (SO2CH3) or sulfamoyl (SO2NH2) group.
For hDHFR, the only substantial structural change is associated with a subdomain rotation that opens the active site cleft and causes helix αF to slide relative to neighboring secondary structural elements; most of the residues that pack against this helix exhibit rotamer disorder in all complexes studied and may lubricate the movement of the helix.
Structural elements also differ.
But they are not merely structural elements.
The program's central structural elements were three Magnificat settings.
As she wrote, two other structural elements emerged.
Motives from each song become structural elements of the next.
The NGOs and future owners will continue to fund the structural elements of the shacks.
Now those floors have been reduced to their structural elements: naked columns and beams.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com