"substantial structural changes" is a correct and usable phrase in written English.
You can use this phrase when referring to significant or major modifications to the underlying structure of something. For example, "The company is making substantial structural changes to their organization in response to the changing economic landscape."
However, it is difficult to clearly establish a direct relationship between their structure and antiproliferative activity, as substantial structural changes might not only affect their anticancer activity but also tightly control their activation site(s) and/or their biological target(s).
Aptamers can undergo substantial structural changes upon target binding or preassemble certain secondary structures to fit a target.
During chronic viral infections such as HIV, these lymphoid tissues undergo substantial structural changes.
A court-appointed monitor has been watching over the force since 1999, when the state admitted that officers had routinely discriminated against black and Hispanic drivers, but many civil rights leaders are pushing for more substantial structural changes.
The comparison of NMR spectra of matrix protein with its myristoylated form revealed substantial structural changes induced by this fatty acid modification.
Cecilia Elena Rouse, Jane Hannaway, Dan Goldhaber, David Figlio use this program as an experiment to see how under-performing schools actually responded.They found schools that received low grades were more likely to make substantial, structural changes.
Energy systems are subject to substantial structural change, mainly due to environmental reasons and concerns about supply security.
It projects 21,880 new lawyer jobs per year through 2020, in part because the legal profession is undergoing substantial structural change.
From its origins around 800 BC to its final dissolution in AD 476 with the demise of the Western Roman Empire, Rome's military organization underwent substantial structural change.
In conclusion, the best explanatory model for our results and those previously published would be the occurrence of a substantial structural change of the PTEN protein, which would preclude its activity as phosphatase and would establish the existence of a role not previously described for this tumor suppressor.
For hDHFR, the only substantial structural change is associated with a subdomain rotation that opens the active site cleft and causes helix αF to slide relative to neighboring secondary structural elements; most of the residues that pack against this helix exhibit rotamer disorder in all complexes studied and may lubricate the movement of the helix.
