In particular, given that both LSC ("LSC", green, solid,) and mobHSC ("Mob", blue, solid) exhibit substantial expansion of the stem cell population, we were surprised to find no overlap of significantly enriched genes in these populations.
Still, stem cells made by nuclear transfer could have substantial advantages over existing stem cell lines for studying basic processes of human development.
Stanford University, the University of California, San Francisco, and the University of Wisconsin, Madison, already are pulling in substantial private funds for stem cell research.
An increase in the production of progenitor cells leads to a larger number of those cells, and thus a decrease in the dedifferentiation rate will need to be enhanced in order to have a substantial effect on the stem cell population.
Several studies have reported that intrinsic natural variation between animals warrants the use of substantial animal numbers when comparing stem cell numbers between littermate pairs[37], [38].
WISH of wild-type worms revealed a stem cell-like expression pattern with substantial expression peripheral to the stem cell compartment.
Furthermore, neither sorting nor growth factor supplementation was required for generation of spheroids from unsorted Brca1 cell lines that had a substantial population of cells expressing stem cell markers.
Several studies have demonstrated a substantial enrichment of stem cells within the CD44+/CD24− fraction of breast tumors and breast cancer cell lines.
Polls show a substantial majority of Americans support embryonic stem cell research.
There is emerging scientific consensus that these stem cell lines retain substantial genetic characteristics of the parent/donor somatic cell or tissue [ 6, 7].
