However, pure photon transport from the emission site to the final photon absorption in the gamma camera crystal requires substantial simulation times to generate images with low noise.
Substantial simulation studies have been performed to demonstrate the efficiency of the multi-stage procedure over the traditional once-and-for-all sampling.
To evaluate our scheme, substantial simulation results are presented and the conclusion is twofold: (1) Our proposal is not far from the optimal.
Successive part of review addresses identification of critical quality attributes, quality target profile of product, criticality in selection of process parameters and material for substantial simulation in laboratory scale and production for successful technology transfer.
However, accurate ARF requires a substantial simulation of all parameter values, which are not always easily implemented in the simulations, e.g., the commonly used energy resolution model might not be useful for high-energy photons and the complex structure of the backscattering components makes the simulation challenging [36, 37].
Substantial numerical simulations have emerged to reproduce in vivo cartilage behavior [ 7– 10].
We appreciate this was a major weakness of the previous manuscript and have carried out substantial new simulations and analysis of experimental data to address the point at length.
Substantial computer simulations can search for an 'optimal' design that addresses all these issues, but experienced clinicians must play a major role to ensure the optimality criteria are practical and clinically realistic [ 8].
The partitioner, the parallel matrix building and solving method result already in substantial transient simulation speedups.
The simulation of large-scale patterns of precipitation has improved somewhat since the AR4 and substantial progress in model simulations of extreme events have been achieved since the AR4.
