Sentence examples for substantial side effects from inspiring English sources
The FOLFIRINOX chemotherapy regimen using four drugs was found more effective than gemcitabine, but with substantial side effects, and is thus only suitable for people with good performance status.
Although these interventions are effective in reducing cancer risk [ 10– 12], they also have substantial side effects.
These treatments have variable effectiveness in treating ITP, and may often be associated with substantial side effects [ 4].
These alternative treatments include oral corticosteroids, which have substantial side effects; omalizumab, a parenterally administered monoclonal antibody directed against IgE that can be effective in individuals with IgE-mediated allergic asthma; and bronchial thermoplasty, a recently introduced approach that requires several invasive bronchoscopic procedures.
Successful, precisely deployed efforts might nonetheless have unpredictable and substantial side effects or unpleasant distributional costs.
Given these substantial side effects, the preferred dose of Furo for inducing a salt appetite should not exceed 2.0 mg.
However, uptake of these therapies was low due to their relatively limited effectiveness, long and complex regimens and substantial side-effects [ 22].
Several studies in small cohorts of patients have shown that the administration of intravenous ibandronate, pamidronate, and zoledronic acid has a prophylactic effect regarding vertebral fractures in the absence of significant side effects, without incurring substantial variations in kidney function (grade C recommendation).
Talc pleurodesis is the conventional management but requires hospitalisation (and substantial healthcare resources), can cause significant side effects, and has a suboptimal success rate.
In addition to stimulating intake of concentrated salt, some of them produce substantial side-effects like reduced food intake and weight gain.
Current treatments have low success rate and substantial side-effects (Baldwin, 2008; Baldwin et al., 2010; Ravindran and Stein, 2010).
