Sentence examples for substantial shutdown from inspiring English sources

The immediate response of a cell on imposition of a detrimental stress is to take evasive action, which is exhibited by a substantial shutdown of transcription.

In 32D-V559D cells, imatinib, flumatinib, and sunitinib treatment all effectively abolished the phosphorylation of KIT, ERK1/2, and STAT3 (Fig. 2), showing substantial shutdown of the KIT and downstream signaling pathways.

"The hit to consumer and business confidence from such an outcome could be substantial, increasing the shutdown's effects," Gennadiy Goldberg, a United States strategist at TD Securities, wrote to clients on Monday.

The descriptive statistics illustrate that there is substantial variation in the shutdown rates across industry and time.

This will assure that neither Chrysler, nor our suppliers would suffer the substantial losses caused by the plant/production shutdowns that result from stop shipments or other disruptions.

One major shutdown has been completed with substantial in-vessel and ex-vessel tasks, and various small enhancements have been installed.

Politically, Republicans are reeling, bearing a substantial amount of the blame for the government shutdown and stalemate.

His office estimates that 275 direct jobs will be lost from the planned shutdown of two local plants, a substantial loss for Burney, with its population of just over 3,000 people, and similarly sized nearby towns.

Union officials said there was no progress, while a spokesman for the transit system, which faces a possible shutdown at 12 01 a.m. tomorrow, insisted that progress had been substantial.

She also said the shutdown was not linked to rising commodity prices, and insisted the factory could reopen, after substantial investment, in two years time.

"It appears that substantial [Affordable Care Act] implementation might continue during a lapse in annual appropriations that resulted in a temporary government shutdown," the report says.