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That is a substantial shift in British politics and a healthy one.
The declaration would represent a subtle but substantial shift in policy.
Bush administration officials said they did not yet see any substantial shift in Japan.
But soon Tory started to long for a more substantial shift in status.
Some health care advocates in the city applauded what they saw as a substantial shift in the mayor's position.
So the bottom line is this: the Gallup poll indicates a pretty substantial shift in the partisan climate.
The results of two new studies may signal a substantial shift in the way psychiatrists and researchers think about treatment for severely depressed patients.
It describes a substantial shift in the racial and ethnic makeup of farmworkers in the Hudson Valley since the 1980s, from mostly black to predominantly Hispanic.
The loss of Glenn, who has five interceptions, could cause a substantial shift in the N.F.L.'s third-ranked pass defense.
And in the midst of such a far-reaching monetary experiment, the effect on the market of any substantial shift in BoJ policy is unpredictable.
The deal sets in motion a substantial shift in fiscal policy at a moment when the economic recovery appears especially fragile.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com