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Exact(1)
The fact that this gene is apparently only found in 18 arthropods (of all of those with substantial sequences in public databases) would suggest either a loss of such a gene in most arthropods lineages or more than one independent horizontal gene transfer event in T. urticae and the Lepidoptera.
Similar(59)
Despite substantial sequence variation in snoRNA homologs in different vertebrates, they can be easily identified by the same antisense elements.
Three of these genes (odd, bowl, sob) share substantial sequence similarity in the regions we targeted for knockdown in T. castaneum; therefore, we do not distinguish specific roles for each of these genes.
We developed highly-sensitive and simple real-time PCR assays for nine key drug resistance mutations and show that these tests overcome substantial sequence heterogeneity in HIV-1 clinical specimens.
This is consistent with the explanation that extensive recombination has introduced substantial sequence divergence in many genes.
In addition, the primers used in the PCR may target regions of the NiV N protein that exhibit substantial sequence divergence in a Nipah-like virus.
The fact that there are no significant land plant hits suggests that these proteins were lost or underwent substantial sequence divergence in the early land plants.
This could be an indication of the differences in the amplification profile between the two progeny or it may be a reflection of a lack of substantial sequence coverage in SC05.
Therefore, when our finding is cautiously interpreted at the gene level, it indicates that even gene families that are well-distributed among widely divergent lineages have undergone substantial sequence evolution in the environment.
Type IVa prepilins, some of which have leader peptides as long as 18 residues, share substantial sequence homology in their N-terminal hydrophobic stretch (Fig. 3) and they are by far the most widespread, being found both in pili and pseudopili (Giltner, Nguyen and Burrows 2012).
PWMs have also been applied in modeling splicing signals beyond the 'essential' two-base-pair splice sites at either end of introns (known as the splice donor and acceptor sites; Figure 1) as there are still substantial sequence preferences in the flanking regions, which serve to guide the splicing machinery.
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