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Exact(19)
If these were not tRNA genes, then it would seem extremely unlikely that the same relative stretch of DNA in both species would happen to have the potential to serve as the template for the same type of tRNA molecule, to exhibit substantial sequence similarity, and to have similar inferred secondary structures.
However, many of these inferences are limited to proteins with substantial sequence similarity.
This cut-off was the most stringent parameter setting applicable and ensures that the datasets show no substantial sequence similarity.
These include three proteins, named Ssp1 3, that differ from Ssp4 but share substantial sequence similarity with one another [16], [21], [22].
In contrast, there is no evidence of any non-orthologous interaction involving any of the genes in the 84A array that lack or have minimal repetitive sequence as visualized by dot plot, despite the fact that all genes in this array necessarily share substantial sequence similarity.
If the sequences to be aligned share substantial sequence similarity, the number of bifurcation points within the POG stays low and allows rapid computation of the multiple alignment.
Similar(41)
All the candidate gene sequences upon alignment with known databank sequences of MTBC, MAPC, MAIC and other non-tuberculous mycobacteria (NTMs), revealed substantial sequence similarities between MIP and MAC as well as MAIC bacilli.
Comparison of Sitka spruce sequences against angiosperm plants suggests that there are likely a substantial number of genes in the collection of 6,464 FLcDNAs that are either absent in other species, or lack significant sequence similarity for unambiguous identification.
First, BLASTp analysis was used to identify a template that shared significant sequence similarity to a C. tritonis echotoxin sequence.
More than six million significant sequence similarities to the SEED protein database were obtained (Supplementary Table 1).
Herein, synteny information is used as the first criterion to define orthology, although substantial local sequence similarity as expressed by BLAST scores is still required.
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