Circular dichroism and nuclear magnetic resonance spectra of all engineered variants demonstrate that they maintain their native conformations despite substantial sequence modification.
The Eday Group is the name for a substantial sequence of sandstones that is found at many locations in Orkney, for which Eday and the area around Eday Sound are the type area.
This has always been a paradoxical finding given the substantial sequence conservation between these proteins [4].
However, many of these inferences are limited to proteins with substantial sequence similarity.
Also the substantial sequence differences often seen in the shared effectors may also confer differences between typical and atypical EPEC.
This cut-off was the most stringent parameter setting applicable and ensures that the datasets show no substantial sequence similarity.
Subsequently, we addressed the question whether the various MAP3Ks, which share substantial sequence homology (figure 4A) in their kinase domain, have identical or different substrate specificities.
When protein-coding genes are subjected to occasional mutations over long time periods, they manage to undergo substantial sequence change while maintaining their original function.
These include three proteins, named Ssp1 3, that differ from Ssp4 but share substantial sequence similarity with one another [16], [21], [22].
A second germination-specific catalase with substantial sequence diversity is a candidate protein that may explain the enhanced peroxide resistance of B. pumilus spores.
Indeed, sequence analysis of these duplicated fish STIMs reveals substantial sequence divergence even in the conserved protein domains (Figs. 3 and 4).
