Sentence examples for substantial selectivity for from inspiring English sources
However, the β5c-selective inhibitor compound 14, which was the most isoform-selective compound in vitro, displayed substantial selectivity for the constitutive proteasome in cells.
The novel pyrazole Pyr10 displayed substantial selectivity for TRPC3-mediated responses (18-fold) and the selective block of TRPC3 channels by Pyr10 barely affected mast cell activation.
Interestingly, the sulphonamide-substituted compound Pyr10, by contrast, showed substantial selectivity for TRPC3-ROCE, being 18-fold (1.25 OM) more potent as compared with the SOCE model.
Imatinib, flumatinib, and sunitinib all showed low potency against 32D cells grown in the presence of IL-3 (IC50 values >5000 nM; Table 1), indicating a substantial selectivity for inhibition of KIT-transformed cells.
The designation 'CSI' should indicate a drug that not only shows substantial selectivity in vitro and preferably ex vivo using the whole blood assays for COX-1 and -2, but also substantial differentiation from conventional NSAIDs with respect to upper gastrointestinal damage in reasonably long studies of endoscopic and gastrointestinal outcomes.
However, although the binding strength was lower, both media exhibited substantial selectivity at pH 7.5.
The hydrosilylation of allyl compounds is very important for the industrial production of γ-substituted propylsilanes; however, it is also a process known to suffer from either substantial selectivity issues or short catalyst lifetimes.
There was substantial selectivity in some orders.
Subtle structural differences, which may be distributed over ubiquitin's and NEDD8's entire surfaces, also contribute substantial selectivity.
The substantial improvement in selectivity for ML241 and the remarkably clean profile for ML240 bode well for their utility as in vivo probes and the therapeutic potential of this chemotype in general.
The compounds 24 26 demonstrated substantial binding affinity and selectivity for A2AR as compared to SCH58261, a standard A2AR antagonist.
