Sentence examples similar to substantial selection of mutations from inspiring English sources

We also demonstrate negative selection of mutations that may be deleterious to tumor development indicating novel avenues for therapy.

Typically, a strong correlation between amino acid mutations is interpreted as evidence of functional interactions under substantial selection pressure.

In the context of modern evolutionary synthesis, it is equally obvious that tumor evolution should involve substantial purifying selection against mutations impairing proliferation.

High burden and pervasive positive selection of somatic mutations in normal human skin.

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Martincorena I, Roshan A, Gerstung M et al. High burden and pervasive positive selection of somatic mutations in normal human skin.

Consequently, a selection of adaptive mutations that may account for the observed translation effects seems unlikely (Fig. 3d, e).

Martincorena, I. et al. High burden and pervasive positive selection of somatic mutations in normal human skin.

What can natural selection of "random" mutation do?

Stably deleting XRN1 can lead to selection of adaptive secondary mutations that might cause indirect effects.

These tumors all have substantial numbers of total mutations in the p53 database (between 750 and 1600).