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We undertook substantial scenario analyses, including combinations of favourable and conservative vaccine assumptions, to provide estimates of the upper and lower bounds for impact and cost effectiveness.
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The results from our simulation study show that the outcome of vaccination would be better in the majority of scenarios/subgroups (RR<1 in 63.9% of scenarios considered) but worse in a <span class="lh">substantial proportion of scenarios considered (RR ≥1 in 36.1% of the scenarios).
For EORTC and PERCIST evaluations, agreement levels were moderate to substantial for the scenario OSEMPET1/PSF ± TOFPET2 and PSF ± TOFPET1/OSEMPET2, with wide confidence intervals.
In the +3°C scenario, substantial areas of the southern US and Central America will transition into high risk and some areas will develop extreme risk.
For Kenya to achieve substantial increases beyond Scenario 2, the international community and Kenyan government must find financing options that make the cost of accessing new ACT drugs more affordable to poor rural households [ 14].
In the High scenario, substantial economic growth and fast convergence of the economies and of the living standards are expected for all European countries, boosting the overall mobility within Europe and reducing the push factors to emigrate from the less developed regions, including Central and Eastern Europe.
The overall direction of the bias can be up or down depending on the genetic architecture of the trait, but it can be substantial in realistic scenarios.
Robust M-estimators bring substantial benefits in this scenario because, rather than relying on classical Gaussian ML estimation, they are based on modeling the contamination noise of the measurements as heavy-tailed process.
Air temperature reduction (a 1.5 °C reduction) is the most profound for the high SVF scenario, whereas substantial radiation shading (Tmrt reduced to 34 °C) is detected in areas with medium-low SVFs.
The proximity of the neighborhood to the plant and the opportunities for contact with the waste rock created a scenario for substantial nonoccupational exposure to asbestos.
A scenario of substantial gene flow was supported by Palo et al. [ 16], showing weak differentiation at microsatellite loci between the northern and southern parts of the lake.
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