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Very few articles are available in literature that present failure analysis based on a substantial sample size of real die breakdowns.
Although there is an increase in the planned sample size under these designs, due to the sequential nature, substantial sample size reductions compared with the single-stage design is also possible not only in the case of clear efficacy but also in the case of complete lack of efficacy of the new treatment.
A strength of the present study was the substantial sample size, which allowed precise estimation of associations over a wide range of exposure intensities and in detailed joint exposure categories.
An important strength of this qualitative study is the substantial sample size (n = 30).
Data collection ceased when a substantial sample size [ 50] produced clear, supportable claims.
However, with the substantial sample size and high response rate, the potential biases are minimized.
Similar(33)
The remaining variants could represent genuine novel low-impact type 2 diabetes variants; however current data do not support this notion and substantial sample sizes are needed to clarify a possible association.
Effective parameter estimation for such mixture models would require substantial sample sizes thereby limiting these approaches to large, well-defined cohorts.
Means were calculated over blocks of years over which length-at-age varied little to obtain substantial sample sizes at each age.
In addition, we acknowledge a need for bigger sample sizes, since complicated models with several parameters require quite substantial sample sizes, as do gene-environment interaction analyses (53, 54).
Second, one might argue that the effect sizes of the genetic variants measured here may have been too low to detect even with the substantial sample sizes available to us.
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