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The phrase "substantial sadness" is correct and usable in written English
It can be used to describe a significant or considerable level of sadness experienced by someone. Example: "After hearing the news, she was overwhelmed by a substantial sadness that lingered for days."
Similar(60)
In the first survey after 9 months, there was a substantial proportion who reported sadness and avoidance reactions in both the directly and indirectly affected groups, and the directly affected had more feelings of guilt and nightmares.
His Al Lewis is weighed down by a gravity that's compounded of his own substantial flesh and an aggrieved sadness to match.
While all responses were consistent in terms of whether advertisements evoked positive or negative emotional responses, there was substantial variation in the specific emotion evoked (for example, fear, sadness or guilt, happiness or satisfaction).
This transition represented a substantial loss to the individual and was most often marked by feelings of guilt, inadequacy, sadness, frustration and the questioning of self identity.
This paper hypothesizes a phenomenon myopic misery in which sadness creates a myopic focus on obtaining money now versus later, increasing intertemporal discount rates and thereby producing substantial financial costs.
Say, sadness?
And sadness.
Expressing sadness.
Honour sadness.
Unspeakable sadness.
Great sadness.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com