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Substantial resting heart rate elevation is associated with increased CV mortality, and drugs that prolong cardiac repolarisation carry a risk of provoking adverse CV events [ 109, 110].
In contrast to wild-type channels, substantial resting K+ currents were present in oocytes expressing homomeric Kir6.2-T293N/SUR1 (homT293N) channels (Fig 2A C).
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Raban's already substantial reputation rested on a series of books that found shelf-room in bookshops' Travel sections, and were united by their fascination with water: he steered a skiff through the rich soup of the Mississippi in Old Glory, sailed solo around Britain in Coasting, crossed the Atlantic in a container ship in Hunting Mister Heartbreak, and in Bad Land, prayed for rain.
Swine is also the only species so far known to hold a substantial number of resting extrathymic CD4+CD8+ T-cells [ 10, 20- 22].
In the ADDITIONS study, the addition of ivabradine led to a further substantial reduction in resting heart rate without excessive bradycardia.
Both doses of ivabradine were associated with a substantial reduction in resting heart rate: 10 bpm with ivabradine 5 mg twice daily (from 71 to 62 bpm) and 12 bpm with ivabradine 7.5 mg twice daily (from 71to5959 bpm) [ 24].
As Mg2+ is always present inside the cell, and ATP concentrations probably lie above 1 mM in physiological conditions (Gribble et al, 2000), these results suggest that there will be a substantial increase in the resting whole-cell KATP currents for both hetT293N and homT293N channels, as observed experimentally (Fig 2A C).
If the demand for independence were about anything substantial, it surely rested on the idea that things could be done differently.
This makes it hard to provide an substantial explanation that rests on previous empirical findings and goes beyond speculation.
Erik Parker's laurels are not substantial, but neither is he resting on them.
These results suggest that tonic activation of PI3K under resting conditions is substantial, and that treatment with DEA/NO did not detectably increase global PKB activation in the slice.
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