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"substantial research interest" is correct and usable in written English.
You could use it when you want to describe an intense curiosity or enthusiasm for something that has been studied or investigated. For example, "John has a substantial research interest in the history of ancient Egyptian architecture."
Exact(11)
The morphology- and size-tunable synthesis of nanocatalysts has attracted substantial research interest especially in catalysis.
Recognizing the fact that not all tasks are uniformly related, there is substantial research interest in modeling task relationships in the state-of-the-art MTL methods.
The role of carboxylesterases as lipid hydrolases (lipases) functioning in energy homeostasis and human metabolic diseases has attracted substantial research interest.
Flexible energy storage devices gained lot of substantial research interest in the recent decade as their special features and potential applications in different portable electronic devices such as smart sensors, actuators, mobiles, flexible touch screens and electronic newspapers, etc.
In the recent years, the natural killer (NK) cell genetic system, regulated by the activating and inhibitory Killer Immunoglobulin-like Receptors (KIR) has garnered substantial research interest as a modifier of HCT outcomes.
Migrant mortality has attracted substantial research interest.
Similar(48)
Among various semiconductor materials, ZnO always gains substantial research interests due to its wide band gap (3.37 eV) and high excitation binding energy (60 meV) at room temperature, making it prominent for a wide range of applications [13].
24 Evaluations of factors that may predict differential treatment response become more pressing when a drug fails in late stage trials after substantial research investment; there is then intense interest in moving from targeting all people to identifying those specific patients who may benefit.
Substantial research has shown that this is not the case.
The UK research endeavour would be significantly scaled back with the loss of substantial research funding.
Her major research interest was suicide prevention.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com