Similar(8)
These results are in contrast with those of van Os et al. [ 31] who found no substantial change in remission rates when including two PANSS items (namely, depression and suicidality) to the eight "core symptoms".
Schizophrenia is a severe psychotic disorder characterized by a chronic and relapsing course with generally incomplete remissions, substantial functional decline, frequent psychiatric and medical co-morbidities and increased mortality [ 1].
The fact that BTK and PI3Kδ inhibitions typically induce partial remissions with substantial residual disease (Byrd et al. 2013; Furman et al. 2014), even after years of continuous therapy (Byrd et al. 2015), suggests that additional therapeutic intervention, such as immune-mediated therapy, is necessary for disease eradication that would allow therapy discontinuation.
However, a substantial percentage of patients in remission or with mildly active disease by DAS28-ESR (50% and 47% respectively) still had CRP levels>3 mg/L (Figure 4a; Table 2).
Cancer may initially be put into remission, either partial (substantial reduction in tumor load) or complete (no evidence of tumor).
Clinically significant pain continues among a substantial proportion of patients in DAS28 remission but not among those in ACR/EULAR remission.
Conclusions: Lamotrigine induced prolonged illness remissions in a substantial number of female patients whose symptoms were both complex and refractory.
In addition, several independent single-institution phase I/II trials using adoptive cell therapy have shown a consistently high response rate, including durable complete remissions in a substantial percentage of treated patients.
Related(15)
substantial relief
substantial penalty
substantial transfer
major remission
substantial discount
substantial remediation
substantial rebate
substantial order
substantial rehabilitation
substantial reimbursement
substantial cancellation
remarkable remission
substantial sentence
substantial rebates
substantial transfers
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