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The phrase "substantial relevance to" is correct and usable in written English
It can be used when discussing the importance or significance of a particular topic or piece of information in relation to another subject. Example: "The research findings have substantial relevance to the ongoing debate about climate change policies."
Exact(6)
Corneal nerves bear substantial relevance to clinicians and scientists alike, given their pivotal roles in regulation of corneal sensation, maintenance of epithelial integrity, as well as proliferation and promotion of wound healing.
Our findings have substantial relevance to public health efforts aimed at improving cervical cancer screening among AI women.
Given that approximately 10% of all pregnant women receive sGC in late gestation to mature the fetal lung, the present study has substantial relevance to clinical practice.
Based on the lipopolysaccharide (O antigen) and the flagellar structures (H antigen) S almonella spp. are divided into greater than 2500 serotypes, of which only few obtain substantial relevance to humans [ 3].
Population-based case probands and both related and unrelated controls are important for assessing the effects of measured genetic variants or haplotypes in candidate genes [ 32], which might have a low individual risk but, when combined, the genetic variants and haplotypes might have a high population attributable risk, with substantial relevance to public health.
The biological plausibility of air pollution (specifically fine particulate matter) affecting health has been discussed by Pope and Dockery (2006), focusing on exposure effects on blood pressure (Brook 2008) and the cardiovascular system (Brook 2008), aspects of substantial relevance to health during pregnancy (Yoder et al. 2009).
Similar(54)
Fourth, recent research demonstrated the importance of habit strength and implicit associations [ 10] indicating substantial relevance of positive implicit associations to strengthen the habit strength health behavior relationship.
Observation of a certain time period of life during which physical activity most strongly influences postmenopausal breast cancer risk would have substantial relevance for targeting age-specific interventions to increase activity.
Despite the fact that findings from general population based studies on the influence of neighborhood on offending carry substantial relevance, one may question the generalizability to specific offender subgroups, such as children with a first police contact.
The emphasis is toward CO2/CH4 separation, considering its substantial and direct relevance to the gas industry.
This parameter is of substantial relevance in quantitative assessment of focal lesions in oncological PET in general.
More suggestions(16)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com