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'substantial regional differences' is correct and usable in written English.
You can use it to describe differences between different geographic regions. For example: "There are substantial regional differences in precipitation levels across Europe."
Exact(26)
Stillbirth rates increased within all regions of Norway and no substantial regional differences were found.
Our study is limited to one urban region and it is possible substantial regional differences in patterns of medication use may occur across Australia.
In contrast to the PM10 association, where substantial regional differences have been reported, our analysis showed most climatic regions had very similar effect size estimates for PM2.5, except for the Mediterranean climatic region.
Moreover, inside autonomous communities substantial regional differences may take place.
Comparisons of perceptions by people with similar attitudes yielded substantial regional differences.
The results revealed substantial regional differences in Fusarium head blight pathogen composition and temporal population dynamics.
Similar(34)
No substantial regional difference was found on the asteroid surface, indicating its homogeneity in composition.
On a scale from 0 to 10, this implies a substantial regional difference in risk perception.
However, there were significant regional differences.
There were significant regional differences.
This overall view masks substantial local and regional differences.
More suggestions(13)
notable regional differences
tremendous regional differences
appreciable regional differences
large regional differences
huge regional differences
important regional differences
crucial regional differences
great regional differences
significant regional differences
substantial geographical differences
noticeable regional differences
major regional differences
marked regional differences
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com