Sentence examples for substantial refinements from inspiring English sources

LEP facilitated extremely precise measurements of the Z particle, which led to substantial refinements in the Standard Model.

Since substantial refinements in the isolation, expansion and transplantation of chondrocytes have been made in recent years, the treatment of early stage osteoarthritic lesions using ACT might now be feasible.

Substantial refinement of the item set was required to establish a consistent model, and a second sample (n = 883) was surveyed to replicate the model.

Now, based on a substantial refinement of the technology, scientists at MIT have conducted the first-ever study of stimulated neural activity in an awake mouse through every visual cortex layer and notably the mysterious subplate below.

For each of these, my reaction is the same: While what TGS said or implied was overbroad and probably needed substantial refinement, that work soon began and was in progress over the 12 years between the two decisions.

Because the diagnosis of concussions has undergone substantial refinement since the 1960s and 1970s, when many of the survey respondents had played, a modern description of symptoms -- such as nausea or seeing stars following a strong blow to the head, not simply being knocked unconscious -- was provided.

Size exclusion chromatography afforded a facile approach to quantify the mass of the unattached polymer, and provide a substantial refinement to estimates of chain graft density beyond traditionally-used approaches, such as thermogravimetry.

The negotiations commonly involved an iterative sequence of discussion and deal changes, frequently involving substantial refinement of the nature of the potential deal as discussions within the acquiring firm proceeded.

However, the current consensus (e.g. Fortnow 2009) is that these approaches are still in need of substantial refinement or that genuinely new methods will be required in order to yield the desired separations.

Application of the conditional Granger analysis resulted in a substantial refinement of the plasticity pattern provided by PGC.

Mapping of ESTs to an existing genome sequence by spliced alignment has allowed substantial refinement of gene models in a number of eukaryotic organisms (e.g. [ 17, 18]).