Sentence examples for substantial protocol from inspiring English sources
Still, there lacks a substantial protocol for prospective monitoring of drug concentrations in the environment and the evident adverse effects.
Failing that, ad-hoc substantial protocol amendments must be made and approved prior to continuing a non-adaptive study.
Any substantial protocol amendments will be sent to the local ethics committee for approval as per standard regulatory requirements at the institution.
Any substantial protocol amendments will be sent to the ethics committee and MHRA for approval as per the standard regulatory requirements.
Any significant safety signals will become known to the CA/REC in any case, as they would either lead to suspension of a study or a substantial protocol and/or RSI amendment.
Changes outside the pre-defined scope of an adaptive protocol, its boundaries or control mechanisms constitute a substantial protocol amendment and require RA/REC approval as specified within legislation [ 6], Figure 1.
Adaptations within that remit are documented using non-substantial protocol amendments which do not require regulatory or ethical review.
Changes within the pre-defined scope, boundaries and control mechanisms of an adaptive study protocol can be documented as non-substantial protocol amendments or in administrative protocol change documents.
A proportion of non-adherence may therefore be reduced by including more substantial monitoring protocols.
CONVINT was terminated after inclusion of n = 252 patients in October 2007 after substantial treatment-protocol changes due to replacement of respective RRT equipment provided by the university hospital (change in contract; machines provided by different supplier; please also refer to Discussion section).
No substantial, shared exegetical protocol or tradition, whether in fully spelled-out statements in so many words, or in the gist of ideas, or in topical conventions, or in intellectual characteristics, governed the two Talmuds' reading of the same Mishnah paragraph.
