Sentence examples for substantial prolongation from inspiring English sources

It seems that unless a substantial prolongation of the mother's life is assured so the child will not be without her at an early age, a doctor's intervention is unethical.

In vivo, electrophysiological testing in db/db mice revealed substantial prolongation of corrected SAN recovery time, indicating abnormal pacemaking function.

In addition to its adverse impact on clinical outcomes, IAT results in substantial prolongation of hospital LOS and increase in hospital costs.

Using paired nRT VB recordings, we recently reported that peri/extrasynaptic α4βδ receptors are recruited during nRT burst firing, leading to a substantial prolongation of burst-mediated phasic inhibition (Herd et al., 2013).

However, deciding whether or not dialysis can offer a substantial prolongation of life expectancy with an acceptable quality of life (QoL) among pre-ESRD (end-stage renal disease) Octogenarians is still a difficult task for nephrologists [ 5, 8- 11].

Most recently, bevacizumab has raised a lot of enthusiasm in the treatment of recurrent glioma with reported response rates of 25%40%%; however, whether this translates into substantial prolongation of survival remains to be demonstrated [ 10, 11].

Although the amplitude of this current is very small compared to peak INa, the slow inactivation kinetic results in a substantial Na+ entry during the action potential (AP) leading to a significant prolongation of the AP duration [ 7, 24].

There was no clinically significant QTc prolongation.

Results: Exposure to 0.8 ppm O3 caused bradycardia, PR prolongation, ST depression, and substantial increases in atrial premature beats, sinoatrial block, and atrioventricular block, accompanied by concurrent increases in several HR variability parameters that were suggestive of increased parasympathetic tone.

On the other hand, if the method has a substantial risk for a false positive result with respect to QTc prolongation, it becomes unattractive for the sponsor, since, as a minimum, an additional TQT study has to be performed in such a case.

Consequences of the latter are relatively easy to predict as ketoconazole-driven CYP3A4 inhibition and subsequent blockade of terfenadine metabolism resulted in substantial increases in terfenadine blood concentrations in combination with potent inhibition of the IKr current resulted in QT interval prolongation and precipitation of TdP arrhythmias.