Sentence examples for substantial problems were from inspiring English sources

The students of explanation who recognized that probabilities as properties of infinite classes posed substantial problems were few, and those who realized that Salmon's position confronted difficulties of its own fewer still.

The other, more substantial problem is her cravenness towards Russia.

Generally, the progress in the field of PMC/NLC trends was substantial and several problems were solved.   5.

It has been previously showed at pilot plant scale that high SO2 removal efficiency is achieved and no substantial problems have been observed while operating in oxy-combustion conditions.

While female donor leukocytes in a male recipient are not expected to cause substantial problems, it is reasonable to expect some issues with male donor leukocytes in female recipients because of the existence of unique proteins associated with y-chromosome gene expression [ 4].

But despite its evident and substantial problems, there was something about it that wouldn't let me stop watching.

These are substantial problems, but they are not new and have all been described previously (Lynch et al., 2010).

Neurological complications of paediatric cancer are a substantial problem and are associated with significant morbidity and loss of quality of life for long-term survivors of paediatric cancer.

That's silly; he's more substantial and his problems are more complicated than that.

The risk of becoming HIV infected in their daily work was acknowledged as a substantial problem: It's very dangerous to work in the CHS.

19 21 If the increases in healthcare costs between those with and without sleep problems are substantial, these excess costs would provide a strong driver for implementing more systematic prevention and treatment.