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"If this review uncovers substantial problems," a memorandum stated, "it would be recommended that additional thought be given to proceeding with the appeal".
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In the present study, by autoclaving and reusing the patient's own bone, we obviated the need to procure an allograft which poses substantial problems in a country like Pakistan.
Other first generation tau tracers, such as [18F]THK5351 ([18F]GE216) [38] 38], have shown even more substantial problems with a large amount of off-target binding to MAO-B that also compromises the interpretation of cortical regions [35].
"She has undergone recent surgery and is in the middle of a rehabilitation period for a substantial problem, though a problem she can recover from.
However, analysts say that even if it gets that, the steel unit would still have substantial problems, such as a number of outmoded plants.
They face substantial problems accessing finance, and remain a place of mystery and intrigue as far as banks and many venture capitalists are concerned.
Because of the intense local news coverage of the Muhammad trial, Mr. Horan, the Fairfax County prosecutor, said he expected "substantial problems" in trying to pick a jury for the Malvo case.
The ACLU's efforts to undermine experts who believe voter fraud is a substantial problem will have a lasting legacy.
The EU faces substantial problems.
There are substantial problems to solve".
Increased long-term sick leave is a substantial problem in many countries, and a major reason for this increase is generally believed to be related to psychosocial stress [1], [2], [3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com