Sentence examples for substantial problem is from inspiring English sources

The other, more substantial problem is her cravenness towards Russia.

The students of explanation who recognized that probabilities as properties of infinite classes posed substantial problems were few, and those who realized that Salmon's position confronted difficulties of its own fewer still.

A third substantial and related problem is that the model is very unclear.

Neurological complications of paediatric cancer are a substantial problem and are associated with significant morbidity and loss of quality of life for long-term survivors of paediatric cancer.

However, resistance remains a substantial problem and is the focus for the development of new therapeutic strategies targeting putative resistance mechanisms.

"The problem is substantial, and the chasm of ignorance is huge".

So, the gender problem is substantial and endemic and getting worse.

The computational cost of optimization method in the optimal well placement problem is substantial.

This problem is substantial, affecting 1.89% of all United States' energy use.

He also believes a substantial part of the problem is that Asian countries, in order to propel their economic growth, rely on undervalued exchange rates to stimulate exports instead of relying on increased domestic consumption.

The magnitude of such a problem is substantial if one considers that in yeast alone there are ∼6000 genes potentially regulated by up to ∼400 proteins, thereby producing ∼6000×2400 possible bound/unbound states.