Sentence examples for substantial problem here from inspiring English sources

However, as allele specific gene expression is due to differential DNA methylation, this may not present a substantial problem here, as Dipterans have lost the main methylation enzymes in their evolutionary history [ 43].

That turnaround by conservative Democrats "says to me that the Democratic leadership came up with a substantial solution to the problem here," said Caroline Fredrickson, director of the Washington legislative office of the American Civil Liberties Union, which has brought two of the wiretapping lawsuits.

The same problem here.

No such problem here.

A similar problem here.

Not a problem here.

"The problem here is a management problem".

"It could become a substantial problem," he said.

There is a problem here.

There is no problem here.

Is there a problem here?