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In Delphi studies aiming to achieve consensus, dropout can be a substantial problem, because one round is largely constructed upon the answers in the previous round.
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Nitrogen (N) leaching is considered a substantial problem in South China vegetable production because of the heavy rainfall and the excessive application of N fertilizer, but quantitative data and effective countermeasures are lacking.
Methyl mercury, the toxic form, even poses a substantial problem for the Arctic, she said, because it can accumulate in polar bears and seals.
Because of the high cost of so many films, many studios have been eager to thwart film piracy, which is a substantial problem for American films in Asia.
"It could become a substantial problem," he said.
"They're unaware of the substantial problem we do have.
The other, more substantial problem is her cravenness towards Russia.
"Sexual misconduct is a serious and substantial problem, and Columbia needs to take it seriously.
What is less clear is whether the trade imbalance will prove to be a substantial problem.
"It's a substantial problem," Botstein recognized.
Neurological complications of paediatric cancers are a substantial problem.
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