However, this huge potential for the understanding of bacterial pathogenesis has not yet been completely realized because of the substantial technical problems associated with accurately measuring bacterial gene expression during real infections.
Type 2 diabetes is a growing public health problem, associated with a substantial burden of morbidity and mortality 1. Patients with diabetes are two to four times more likely to die from cardiovascular disease than those without the disease 2. Lifestyle behaviours, including diet, are strongly associated with risk of incident diabetes and other cardiovascular disease risk factors.
Osteoporosis is a major public health problem associated with significant morbidity and mortality, resulting in a substantial personal burden to patients and caregivers, and an economic burden to individuals and a healthcare system with limited resources.
Because these agents are so widely used, the potential scope of the health problem associated with NSAID related gastrointestinal adverse events is substantial.
Obesity is a major health problem associated with increasing risk of diabetes mellitus, hypertension, heart disease, cancer, decreased life expectancy [ 1] and substantial impact on health-care costs [ 2, 3].
Acute kidney injury (AKI) is a worldwide problem, associated with increasing morbidity and mortality, and can be considered as a systemic inflammatory condition that may have substantial effects on various distant organs [ 1- 3].
Further research underpinned by models of help-seeking which facilitate the design of interventions are required if we are to address the substantial public health problems associated with the common mental disorders of depression and anxiety.
Neurological complications of paediatric cancer are a substantial problem and are associated with significant morbidity and loss of quality of life for long-term survivors of paediatric cancer.
"Don't Blame Wal-Mart," by Robert B. Reich (Op-Ed, Feb. 28), suggests that the best way to forestall the substantial economic and social problems associated with Wal-Mart is to change federal labor and offshoring laws.
The objective is to evaluate the leakage performance of this particular seal arrangement and possible problems associated with the development of a substantial interseal pressure, which have been observed in some experimental studies.
