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The substantial presentation of CD44 and hyaluronate in the inflamed synovium of patients with RA is a good reason to explore the involvement of CD44 in this pathology, but it cannot be considered conclusive evidence on its own.
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After discussion of the main points raised by the referees, two in particular were highlighted as substantial: 1) The presentation of the context for this work and depth of discussion of the results should be improved.
BP wrote the first draft of the manuscript, and TB's suggestions led to substantial improvement in the presentation of the material.
One key component of ICB is the substantial reduction in the presentation of highly specific information that can overwhelm students and obscure the science of biology.
The aim of this paper is presentation of the substantial modification of MFM which enables optimal identification of parameter faults with minimization of time delay.
However, it is of note that there is a substantial variability in the clinical presentation of patients with combined pituitary hormone deficiency even if the same gene is affected and even in subjects with identical mutations.
Presentation of the substantial economic losses for both the public health and agricultural sectors will also, we hope, encourage countries and international organizations to more closely examine potential control programs and cost-sharing methods between the 2 affected sectors (10 ).
There was no substantial seasonality for presentations of cancers of all non-skin sites in the region.
We are grateful to Taryn Lopez and one anonymous reviewer whose insightful and thoughtful comments and suggestions allowed us to make substantial improvements in the science and presentation of this paper.
Some Cochrane systematic reviews, particularly those with narrative presentation of results, are substantial documents, and trade-offs had to be made between detail and key messages.
RBW made substantial contributions to the analysis, interpretation and presentation of data; by performing the statistical analysis and helping to write the results of the study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com