Sentence examples for substantial prerequisites from inspiring English sources

So far, no substantial prerequisites for its ligand DNA have been described (e.g. sequence motifs or nucleotide modifications), beside the DNA needs to be double stranded and of more than 80 bp in length to accomplish sufficient AIM2 inflammasome formation to allow caspase-1 cleavage (Jin et al, 2012).

The reason for these differences may be that patients with bone metastases are a more heterogeneous group including those with one or two bone metastases as well as patients with massive engagement and prerequisites of substantial bone marrow infiltration.

However Ms Jaresko emphasised that a large portion of the package would have to be paid up-front, without the prerequisite of substantial economic reforms.

Such efforts, while substantial, represent the logical prerequisite to the establishment of content validity for the ICBM.

The current guidelines for implanting this cup indicate that complete coverage by dorsal acetabular bone stock is not a prerequisite, as substantial DAR loss may not be the primary determinant of implant-bone interface failurea.

Therefore, even if Ca2+ binding should be a prerequisite for substantial activation of PK, increase in cAMP alone can be expected to lead to a disinhibition of GP, shifting the balance towards glycogen degradation.

Substantial gas infusion is a prerequisite for gas accumulation in the uplift period of tight sand formation.

Until substantial information becomes available, a prerequisite in terms of subcellular co-localization (and tissue distribution) and topology in the case of membrane proteins ensures reliability of the prediction method.

Nevertheless, the indispensable prerequisite of a substantial increase in public funding is challenged by the current economic crisis and domestic political situation.

Achieving CR is not paramount, since it is not a prerequisite for obtaining a substantial survival benefit.

Previous MD results [33, 52] concluded, that finding prerequisite binding sites is a substantial advantage of the MD simulations.