The phrase "substantial potency" is correct and can be used in written English.
It means having a strong and powerful effect or potential. Example: "The new medicine has shown a substantial potency in treating the disease, with majority of the patients experiencing significant improvement in their symptoms." Another example: "The company's marketing strategy has led to a substantial potency in their sales, resulting in a significant increase in revenue."
Elaboration of a fragment chemical lead established a new lipophilic aryl Tyr interaction resulting in a substantial potency improvement.
Stem cell progeny can include progenitor cells that have substantial potency to proliferate and produce one or more immature precursors that precede the differentiated state.
As a result of thermal instability, some live attenuated viral (LAV) vaccines lose substantial potency from the time of manufacture to the point of administration.
The most active analogue 1 inhibited mushroom tyrosinase with an IC50 of around 0.29 μM and also retained a substantial potency in cell culture by reducing pigment synthesis by 78%.
E. hirta extract exerted broad antibacterial spectrum with substantial potency against both Gram-positive and Gram-negative bacteria tested.
At high ionic strength, substantial bactericidal potency was observed for the longer WWWWW tag down to KNK7-WWWWW.
These results suggest that PC10 could be a promising candidate for passive protection and inform PEDV vaccine design because of its specificity and substantial neutralization potency.
Nonetheless, no one at the workshop would disagree that the concern is real, given what is now known about these compounds' substantial variability, potency, and ability to significantly alter molecular end points and gene expression.
Substantial effectiveness?
Substitution of Thr-6 in native CGRP by either alanine or serine caused substantial decreases in potency in cAMP production; the potency for [Ser]-CGRP was reduced over 10-fold and for [Ala]-CGRP there was almost a 100-fold reduction in potency with a trend towards a reduced Emax.
The tendency of the compounds to fall into two groups in the ER scenario illustrates a substantial difference in potency between the compounds and it was deemed likely that Cmp 1C 1E would have a daily dose below 100 mg.
