Sentence examples for substantial pathology from inspiring English sources

The two total thyroid ROIs without substantial pathology had MRT values of 278 and 350 min overlapping a published 99mTc-MIBI thyroid MRT value.

It is imperative therefore that we find early biomarkers for sporadic Alzheimer's disease, which could identify patients before substantial pathology develops.

It has been suggested that such a dynamic behavior could reflect the fluctuating responsiveness of the immune system to the periodic and transient bursts of mycobacterial replication inside infected lungs and a fine-tuning of the response to control the infection without inducing substantial pathology [1].

Using mouse models, we explored the neuroprotective effect of near infrared light (NIr) treatment, delivered at an age when substantial pathology is already present in the cerebral cortex.

Of these eight, only the first five cause substantial pathology and have been the focus of whole genome sequencing efforts thus far [ 1, 2].

This is not accompanied by any substantial pathology in the brain– indeed histology suggests less focal immune clusters and decreased astrocyte activation.

The substantial pathologies associated with Brd4 silencing are apparently at odds with the limited toxicities reported for BET inhibitors to date.

Pure HS-aging cases lacked substantial additional pathologies AD-type pathology, or Lewy bodies [ 19– 21], as shown in Table  1.

It is likely that our subjects did go on to have further strokes, indeed the post-mortem findings of substantial vascular pathology support the argument that subsequent dementia is due to ongoing vascular pathology, including both macro- and microvascular disease.

The absence of substantial neurodegenerative pathology in the cognitively normal subjects explains the absence of a strong correlation between biomarkers of neuronal pathology and cognition in these subjects.

Substantial AD pathology is often present in advanced age, including in those with minimal or no cognitive impairment at death [17].